Study on the pharmacodynamic material basis of network pharmacology of "Duhuo-sangjisheng" pair in the treatment of Rheumatoid arthritis

Abstract

Rheumatoid arthritis (RA) is a chronic systemic disease with unknown etiology, mainly inflammatory synovitis. Based on the theory background of Duhuojisheng Decoction in “BeiJiQianJin Yaofang”,this paper takes Duhuo Jisheng decoction as the theoretical background, and develops the network pharmacology pharmacodynamic material basis of its compatibility in the treatment of rheumatoid arthritis. Firstly, TCMSP database was used to sort out the effective components and target genes. Next, gene cards database was used to collect disease-related genes, and then a four-dimensional relationship network of "drug-active ingredient-target gene-disease" was established. Finally, PubChem database was used to sort out the predicted components and summarize the pharmacodynamic basis.To some extent, it shows the significance of Duhuo Jisheng Decoction in the treatment of rheumatoid arthritis.