Clinical Analysis of Multidrug Resistance-Related Protein Expression in Gastric Cancer Cells

Abstract

Objective: This study aims to clinically analyze the expression of multidrug resistance-related proteins in gastric cancer cells. Methods: In this study, archival paraffin blocks from 50 surgical specimens of gastric cancer collected in our hospital between 2021 and 2022 were included. Each specimen included tumor lesion tissue and normal gastric mucosa tissue located more than 5 cm away from the cancer. Immunohistochemistry was performed to detect P-glycoprotein (P-gp), glutathione S-transferase pi (GST-π), and B-cell lymphoma-extra-large (Bcl-xL) expression, and the relevant data were collected and analyzed. Results: The positive expression rates and high expression levels of P-gp, GST-π, and Bcl-xL in gastric cancer tissues were significantly higher than in normal gastric mucosa tissues (p < 0.05). The expression of multidrug resistance proteins (P-gp, GST-π, Bcl-xL) in gastric cancer was not associated with patient clinical characteristics (tumor clinical stage, depth of invasion, and lymph node metastasis) (p > 0.05); Bcl-xL expression level was positively correlated with tumor differentiation degree (p < 0.05). Conclusion: The results of this study reveal the expression patterns of multidrug resistance-related proteins in gastric cancer tissues and shed light on the relationship between the expression of these proteins and multidrug resistance in gastric cancer.