Evaluation of the Effectiveness of Traditional Chinese Medicine Dietary Intervention in the Pre-diabetic Population with Type 2 Diabetes Mellitus

Abstract

Prediabetes is a key reversible stage in the development of type 2 diabetes mellitus. Traditional Chinese Medicine dietary intervention, based on the theories of syndrome differentiation and treatment as well as properties, flavors, and meridian tropism, provides an intervention strategy characterized by both metabolic regulation and holistic conditioning for this population. This paper systematically constructs a theoretical framework of Traditional Chinese Medicine dietary intervention for prediabetes, and it clarifies the core disease locations of "Spleen Impairment" and "Food Stagnation" as well as the main susceptible constitutions, including phlegm-dampness, damp-heat, and qi deficiency. Based on the correspondence between properties, flavors, and meridian tropism and modern metabolic regulation, this paper proposes individualized formula preparation principles, a nonlinear dose-effect model, and compliance optimization pathways. Furthermore, it establishes a multi-dimensional evaluation system, which encompasses temporal indicators of glucose and lipid metabolism, a coupling analysis of syndrome scores and energy metabolism, and a hierarchical prediction model of outcome risk. This paper aims to provide a theoretical basis and quantitative evaluation tools for the precise application of Traditional Chinese Medicine dietary intervention.