Evaluation of the Effectiveness of Comprehensive Prevention and Control Measures for Respiratory Diseases in Pig Farming

Abstract

Porcine respiratory disease complex is driven by the synergistic effects of multiple pathogen co-infections and environmental factors. This study elucidates the immune evasion mechanism resulting from the co-infection of porcine reproductive and respiratory syndrome virus and porcine circovirus type 2. It also clarifies the degradation pathway of the mucosal barrier caused by ammonia, temperature and humidity, and high stocking density, as well as the aerodynamically mediated transmission threshold. This study establishes a multi-target intervention system encompassing air purification, immunization program restructuring, and feed additives. By employing interrupted time series analysis, nonlinear decay curve fitting, and a marginal benefit net present value framework, this study conducts a multivariate quantitative evaluation of morbidity, pathogen elimination efficiency, and growth and treatment costs, thereby providing technical parameters for assessing the effectiveness of the prevention and control measures.